A new study based on Moderna’s Phase 3 clinical trial data suggests recipients of Moderna’s COVID-19 vaccine may be more likely to suffer repeated infections, perhaps indefinitely.
by Madhava Setty, M.D.
May 5, 2022
A new study suggests recipients of Moderna’s COVID-19 vaccine may be more likely to suffer repeated infections, perhaps indefinitely.
The study, still in preprint, found participants in Moderna’s adult trial who received the vaccine, and later were exposed to the virus, did not generate antibodies to a key component of the virus as often as did those in the placebo group.
The authors’ findings, which are corroborated by U.K. data that demonstrate the rates of infection are significantly higher in the vaccinated, suggest Moderna knew of this safety signal in 2020 when the vaccine maker was conducting its trials.
The authors of “Anti-nucleocapsid antibodies following SARS-CoV-2 infection in the blinded phase of the mRNA-1273 Covid-19 vaccine efficacy clinical trial“ wrote:
“Among participants with PCR-confirmed Covid-19 illness, seroconversion to anti-N Abs at a median follow up of 53 days post diagnosis occurred in 21/52 (40%) of the mRNA-1273 vaccine recipients vs. 605/648 (93%) of the placebo recipients (p < 0.001).”
Vaccinated participants in the trial who developed breakthrough COVID-19 — meaning they received a positive PCR test — mounted an antibody response to the nucleocapsid portion of the SARS-CoV-2 virus less often than did placebo recipients who tested positive for the virus.
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